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KMID : 0363620060270030038
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Journal of Korean Oriental Medicine
2006 Volume.27 No. 3 p.38 ~ p.50
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Effects of Korean Ginseng, Korean Red Ginseng and Fermented Korean Red Ginseng on Cerebral Blood Flow, Cerebrovascular Reactivity, Systemic Blood Pressure and Pulse Rate in Humans
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Jeong Dong-Won
Moon Sang-Kwan
Hong Jin-Woo
Shin Won-Jun
Park Young-Min
Jung Jae-Han
Kim Chang-Hyun
Min In-Kyu
Park Sung-Wook
Jung Woo-Sang
Park Jung-Mi
Ko Chang-Nam
Cho Ki-Ho
Kim Young-Suk
Bae Hyung-Sup
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Abstract
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Objectives: The aim of this study was to evaluate the effects of Korean ginseng (KG), Korean red ginseng (KRG) and fermented Korean red ginseng (FKRG) extracts on cerebral hemodynamics and to compare distinction of each extract.
Methods: Ten healthy male volunteers (26.0{pm}1.8yrs) participated in the study according to double-blind and cross-over protocols. Each volunteer was blindly administered 500mg of KG, KRG, FKRG extract or placebo (Dextrin). Blinded researchers measured changes of hyperventilation-induced cerebrovascular reactivity (CVR), mean blood flow velocity (MBFV) of middle cerebral arteries (MCAs) and corrected blood flow velocity at P_{ETCO2}=40mmHg (CV40) using transcranial Doppler ultrasound (DWL Co., Germany). Researchers also observed changes of mean blood pressure (MBP), pulse rate (PR) and expiratory CO_2 using S/5 Collector (Datex-Ohmeda Co., Finland). The evaluation was performed at basal condition, and repeated at 1, 2, 3, 4 and 5 hours after administration.
Results:
Conclusions: It is suggested that KG, KRG and FKRG extracts have effects of enhancing CVR and thus of increasing cerebral blood flow in human subjects.
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KEYWORD
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Transcranial Doppler (TCD), cerebrovascular reactivity, ginseng, red ginseng, fermented red ginseng, cerebral blood flow velocity
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